The North East Himalaya states, including Sikkim, experience various kinds of natural hazards such as landslides, earthquakes, floods, Glacial Lake Outburst Floods (GLOFs), and cyclonic storms due to their unique geography, climate, and geological positions. These natural hazards not only pose threats to human society but also modify the landform on a local to regional scale. The Sikkim Regional Centre has been involved in in-depth research of these natural hazards, such as GLOF, earthquakes, and landslides, to understand their mechanism, their occurrence intervals, associated landform evolution, and possible impact on society. At present, the centre has been monitoring the glaciers of Sikkim Himalaya and studied the impact of year 2023 Sikkim GLOF and Avalanche events. The centre is also carrying out the landform evolution of Shillong Plateau due to 1897 earthquake. These kinds of studies help to identify the region-specific hazards and possible affected communities and to prepare hazard-specific mitigation strategies from a local to regional scale.